Details-Calcnet-AlzheimerNet

Target name

O00519: Fatty-acid amide hydrolase 1

Protein function

Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

Database links

Uniprot primary ID	O00519
PDB ID
DrugBank ID	DB00818 DB00599
BioGrid ID	108464
GuidetoPHARMACOLOGY ID	1400
PharmGKB ID	PA27955
KEGG ID	hsa:2166
BioCyc	MetaCyc:HS04139-MONOMER
Entrez Gene (Gene ID)	2166
DIP
STRING	9606ENSP00000243167
MINT
IntAct	O00519
DMDM
BREDNA	35199 3514
Rectome
SignaLink
BindingDB	O00519

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.759	0.869	0.794	0.647	0.941	0.805	0.888	0.829	0.699	0.962	Download
MACCS fingerprints	0.759	0.822	0.757	0.767	0.746	0.788	0.856	0.792	0.807	0.778	Download
Daylight fingerprints	0.715	0.730	0.706	0.740	0.672	0.748	0.771	0.736	0.772	0.700	Download
ECFP2 fingerprints	0.850	0.925	0.845	0.875	0.816	0.875	0.947	0.868	0.909	0.826	Download
ECFP4 fingerprints	0.860	0.944	0.861	0.855	0.867	0.884	0.956	0.882	0.886	0.878	Download
ECFP6 fingerprints	0.840	0.928	0.849	0.794	0.905	0.896	0.954	0.898	0.863	0.934	Download

Download datasets

Positive dataset

Negative dataset