Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
| Uniprot primary ID | O95263 |
| PDB ID | |
| DrugBank ID | DB00201 DB00920 |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 1308 |
| PharmGKB ID | PA33142 |
| KEGG ID | hsa:8622 |
| BioCyc | |
| Entrez Gene (Gene ID) | 8622 |
| DIP | |
| STRING | 9606ENSP00000264917 |
| MINT | |
| IntAct | |
| DMDM | |
| BREDNA | 31453 |
| Rectome | R-HSA-418555 |
| SignaLink | |
| BindingDB | O95263 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.976 | 0.999 | 0.976 | 0.976 | 0.976 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | Download |
| MACCS fingerprints | 0.926 | 0.975 | 0.924 | 0.944 | 0.904 | 0.884 | 0.985 | 0.921 | 0.950 | 0.907 | Download |
| Daylight fingerprints | 0.959 | 0.964 | 0.960 | 0.921 | 1.000 | 0.974 | 0.975 | 0.984 | 0.950 | 1.000 | Download |
| ECFP2 fingerprints | 0.988 | 0.999 | 0.988 | 1.000 | 0.976 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | Download |
| ECFP4 fingerprints | 0.996 | 1.000 | 0.996 | 1.000 | 0.992 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | Download |
| ECFP6 fingerprints | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
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