Details-Calcnet-AlzheimerNet

Target name

P00491: Purine nucleoside phosphorylase

Protein function

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

Database links

Uniprot primary ID	P00491
PDB ID	1V45 1V41 1PWY 4GKA 1RFG 3D1V 1V3Q 2OC9 3INY 2OC4 2Q7O 1M73 1RT9 1YRY 3PHB 3GGS 1RR6 2A0Y 2A0X 4EAR 2A0W 1RCT 3BGS 4ECE 1ULB 1PF7 1ULA 3K8O 4EB8 1RSZ 3GB9 1V2H 2ON6 3K8Q
DrugBank ID	DB00242 DB00900
BioGrid ID	110921
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA31694
KEGG ID	hsa:4860
BioCyc	MetaCyc:HS02151-MONOMER
Entrez Gene (Gene ID)	4860
DIP	DIP-50406N
STRING	9606ENSP00000354532
MINT	MINT-1375849
IntAct	P00491
DMDM	108935929
BREDNA	2421
Rectome	R-HSA-74217 R-HSA-74259
SignaLink	P00491
BindingDB	P00491

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.932	0.944	0.929	0.973	0.885	0.923	0.950	0.918	0.964	0.870	Download
MACCS fingerprints	0.936	0.955	0.931	0.991	0.871	0.932	0.980	0.927	0.982	0.870	Download
Daylight fingerprints	0.917	0.919	0.918	0.909	0.926	0.926	0.928	0.927	0.893	0.963	Download
ECFP2 fingerprints	0.919	0.936	0.913	0.982	0.843	0.908	0.963	0.900	0.964	0.833	Download
ECFP4 fingerprints	0.925	0.943	0.920	0.982	0.857	0.915	0.947	0.909	0.964	0.852	Download
ECFP6 fingerprints	0.927	0.943	0.922	0.977	0.866	0.915	0.958	0.909	0.964	0.852	Download

Download datasets

Positive dataset

Negative dataset