Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
| Uniprot primary ID | P00749 |
| PDB ID | 1OWI 1OWH 1FV9 1OWJ 1OWE 1OWD 1VJA 1URK 1C5Z 1C5Y 1C5X 4K24 1F5L 4FUB 1C5W 3OY5 1O3P 1GJD 3OY6 1GJB 1GJC 1GJA 3KHV 4JK6 4JK5 3M61 4JNL 4OS2 1SC8 1U6Q 1GI7 1O5B 1W14 3U73 1GJ7 1GI8 1O5C 1GJ8 1GJ9 4X1R 1SQT 1F92 1F5K 2I9B 4MNX 1OWK 1KDU 1SQA 4JNI 1SQO 4X1N |
| DrugBank ID | DB00013 DB00594 |
| BioGrid ID | 111344 |
| GuidetoPHARMACOLOGY ID | 2393 |
| PharmGKB ID | PA33382 |
| KEGG ID | hsa:5328 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5328 |
| DIP | DIP-46387N |
| STRING | 9606ENSP00000361850 |
| MINT | |
| IntAct | P00749 |
| DMDM | 254763341 |
| BREDNA | 342173 |
| Rectome | R-HSA-75205 |
| SignaLink | |
| BindingDB | P00749 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.714 | 0.804 | 0.736 | 0.698 | 0.769 | 0.715 | 0.839 | 0.745 | 0.694 | 0.788 | Download |
| MACCS fingerprints | 0.713 | 0.802 | 0.730 | 0.711 | 0.747 | 0.712 | 0.825 | 0.751 | 0.712 | 0.780 | Download |
| Daylight fingerprints | 0.694 | 0.735 | 0.710 | 0.697 | 0.721 | 0.745 | 0.790 | 0.769 | 0.731 | 0.801 | Download |
| ECFP2 fingerprints | 0.788 | 0.857 | 0.788 | 0.830 | 0.751 | 0.816 | 0.894 | 0.821 | 0.858 | 0.788 | Download |
| ECFP4 fingerprints | 0.788 | 0.873 | 0.789 | 0.830 | 0.752 | 0.813 | 0.907 | 0.814 | 0.873 | 0.763 | Download |
| ECFP6 fingerprints | 0.779 | 0.862 | 0.787 | 0.797 | 0.777 | 0.804 | 0.912 | 0.810 | 0.843 | 0.782 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
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