Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
| Uniprot primary ID | P00750 |
| PDB ID | 1BDA 1TPK 1PML 1A5H 1TPM 1RTF 1TPG 1PK2 1TPN |
| DrugBank ID | DB00513 DB01050 DB01088 DB00013 |
| BioGrid ID | 111343 |
| GuidetoPHARMACOLOGY ID | 2392 |
| PharmGKB ID | PA33381 |
| KEGG ID | hsa:5327 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5327 |
| DIP | |
| STRING | 9606ENSP00000220809 |
| MINT | MINT-8309345 |
| IntAct | P00750 |
| DMDM | 137119 |
| BREDNA | 342168 |
| Rectome | R-HSA-186797 R-HSA-75205 |
| SignaLink | |
| BindingDB | P00750 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.611 | 0.684 | 0.642 | 0.633 | 0.650 | 0.698 | 0.810 | 0.726 | 0.698 | 0.750 | Download |
| MACCS fingerprints | 0.533 | 0.611 | 0.601 | 0.515 | 0.669 | 0.690 | 0.775 | 0.701 | 0.722 | 0.683 | Download |
| Daylight fingerprints | 0.642 | 0.671 | 0.642 | 0.728 | 0.573 | 0.716 | 0.734 | 0.675 | 0.889 | 0.492 | Download |
| ECFP2 fingerprints | 0.538 | 0.692 | 0.624 | 0.495 | 0.727 | 0.723 | 0.885 | 0.778 | 0.630 | 0.905 | Download |
| ECFP4 fingerprints | 0.682 | 0.769 | 0.712 | 0.699 | 0.723 | 0.868 | 0.925 | 0.880 | 0.852 | 0.905 | Download |
| ECFP6 fingerprints | 0.707 | 0.774 | 0.721 | 0.762 | 0.688 | 0.850 | 0.916 | 0.855 | 0.889 | 0.825 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
All rights reserved.
The recommended browsers: Safari, Firefox, Chrome,IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |