Details-Calcnet-AlzheimerNet

Target name

P00797: Renin

Protein function

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Database links

Uniprot primary ID	P00797
PDB ID	3KM4 1BBS 3K1W 4Q1N 2IKO 3OAG 3Q5H 4XX4 2V0Z 3Q3T 2IKU 4S1G 2FS4 3G6Z 4RYG 4AMT 4GJ5 2V16 4GJ7 4GJ6 2V13 2V12 1RNE 2V10 4GJ9 4GJ8 2I4Q 3G72 2BKS 3G70 2BKT 3OQK 3OAD 3OQF 3OWN 3Q4B 3VCM 2IL2 2X0B 3OOT 2G1N 2G1O 3SFC 2G1R 4GJD 4GJC 4RZ1 3VSX 2REN 1HRN 3D91
DrugBank ID	DB00212
BioGrid ID	111904
GuidetoPHARMACOLOGY ID	2413
PharmGKB ID	PA297
KEGG ID	hsa:5972
BioCyc
Entrez Gene (Gene ID)	5972
DIP	DIP-59219N
STRING	9606ENSP00000272190
MINT	MINT-1381167
IntAct	P00797
DMDM	132326
BREDNA	342315
Rectome	R-HSA-2022377
SignaLink
BindingDB	P00797

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.845	0.896	0.851	0.813	0.888	0.860	0.919	0.863	0.827	0.900	Download
MACCS fingerprints	0.862	0.919	0.860	0.869	0.851	0.856	0.925	0.855	0.859	0.851	Download
Daylight fingerprints	0.845	0.870	0.852	0.805	0.900	0.867	0.889	0.871	0.832	0.910	Download
ECFP2 fingerprints	0.880	0.947	0.884	0.853	0.915	0.895	0.961	0.897	0.866	0.930	Download
ECFP4 fingerprints	0.898	0.949	0.901	0.866	0.936	0.925	0.965	0.926	0.906	0.946	Download
ECFP6 fingerprints	0.876	0.940	0.883	0.823	0.944	0.908	0.963	0.911	0.871	0.953	Download

Download datasets

Positive dataset

Negative dataset