Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
| Uniprot primary ID | P01275 |
| PDB ID | 1BH0 2G49 1D0R 2L64 1NAU 4APD 2M5P 2M5Q 2L63 3IOL |
| DrugBank ID | |
| BioGrid ID | 108911 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA28606 |
| KEGG ID | hsa:2641 |
| BioCyc | |
| Entrez Gene (Gene ID) | 2641 |
| DIP | DIP-46470N |
| STRING | 9606ENSP00000387662 |
| MINT | MINT-8090511 |
| IntAct | P01275 |
| DMDM | 125987831 |
| BREDNA | |
| Rectome | R-HSA-420092 R-HSA-416476 R-HSA-381676 R-HSA-422085 R-HSA-381771 R-HSA-418555 R-HSA-163359 |
| SignaLink | |
| BindingDB | P01275 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.981 | 0.995 | 0.981 | 0.962 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | Download |
| MACCS fingerprints | 0.966 | 0.981 | 0.967 | 0.933 | 1.000 | 0.977 | 1.000 | 0.981 | 0.955 | 1.000 | Download |
| Daylight fingerprints | 0.966 | 0.967 | 0.967 | 0.933 | 1.000 | 0.977 | 0.977 | 0.981 | 0.955 | 1.000 | Download |
| ECFP2 fingerprints | 0.971 | 0.993 | 0.971 | 0.943 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | Download |
| ECFP4 fingerprints | 0.976 | 0.995 | 0.976 | 0.952 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | Download |
| ECFP6 fingerprints | 0.981 | 0.981 | 0.981 | 0.962 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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