Target name

P01275: Glucagon


  Protein function

Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.

  Database links

Uniprot primary ID P01275
PDB ID 1BH0 2G49 1D0R 2L64 1NAU 4APD 2M5P 2M5Q 2L63 3IOL
DrugBank ID
BioGrid ID 108911
GuidetoPHARMACOLOGY ID
PharmGKB ID PA28606
KEGG ID hsa:2641
BioCyc
Entrez Gene (Gene ID) 2641
DIP DIP-46470N
STRING 9606ENSP00000387662
MINT MINT-8090511
IntAct P01275
DMDM 125987831
BREDNA
Rectome R-HSA-420092 R-HSA-416476 R-HSA-381676 R-HSA-422085 R-HSA-381771 R-HSA-418555 R-HSA-163359
SignaLink
BindingDB P01275

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.981 0.995 0.981 0.962 1.000 1.000 1.000 1.000 1.000 1.000 Download
MACCS fingerprints 0.966 0.981 0.967 0.933 1.000 0.977 1.000 0.981 0.955 1.000 Download
Daylight fingerprints 0.966 0.967 0.967 0.933 1.000 0.977 0.977 0.981 0.955 1.000 Download
ECFP2 fingerprints 0.971 0.993 0.971 0.943 1.000 1.000 1.000 1.000 1.000 1.000 Download
ECFP4 fingerprints 0.976 0.995 0.976 0.952 1.000 1.000 1.000 1.000 1.000 1.000 Download
ECFP6 fingerprints 0.981 0.981 0.981 0.962 1.000 1.000 1.000 1.000 1.000 1.000 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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