Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:
| Uniprot primary ID | P01375 |
| PDB ID | 2ZPX 1A8M 5TSW 4TSV 2AZ5 2ZJC 2E7A 3IT8 2TUN 1TNF 3ALQ 3WD5 3L9J 4TWT 4G3Y |
| DrugBank ID | DB00051 DB00608 DB01411 DB00668 DB00065 DB01427 DB00852 DB01296 DB01041 DB08904 DB01407 DB06674 DB08910 DB00005 |
| BioGrid ID | 112979 |
| GuidetoPHARMACOLOGY ID | 2635 |
| PharmGKB ID | PA435 |
| KEGG ID | hsa:7124 |
| BioCyc | |
| Entrez Gene (Gene ID) | 7124 |
| DIP | DIP-2895N |
| STRING | 9606ENSP00000398698 |
| MINT | MINT-1131842 |
| IntAct | P01375 |
| DMDM | 135934 |
| BREDNA | |
| Rectome | R-HSA-75893 R-HSA-5357786 R-HSA-381340 R-HSA-5668541 |
| SignaLink | |
| BindingDB | P01375 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.563 | 0.697 | 0.676 | 0.418 | 0.933 | 0.577 | 0.709 | 0.668 | 0.439 | 0.913 | Download |
| MACCS fingerprints | 0.554 | 0.656 | 0.625 | 0.467 | 0.783 | 0.612 | 0.726 | 0.652 | 0.531 | 0.781 | Download |
| Daylight fingerprints | 0.593 | 0.674 | 0.671 | 0.481 | 0.859 | 0.610 | 0.676 | 0.662 | 0.510 | 0.825 | Download |
| ECFP2 fingerprints | 0.576 | 0.734 | 0.684 | 0.430 | 0.937 | 0.617 | 0.787 | 0.702 | 0.464 | 0.956 | Download |
| ECFP4 fingerprints | 0.574 | 0.762 | 0.696 | 0.411 | 0.979 | 0.630 | 0.795 | 0.718 | 0.464 | 0.989 | Download |
| ECFP6 fingerprints | 0.561 | 0.717 | 0.693 | 0.393 | 0.992 | 0.585 | 0.755 | 0.697 | 0.413 | 1.000 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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