AlzheimerNet
  Target name

P02766: Transthyretin

  Protein function

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

  Database links
Uniprot primary ID P02766
PDB ID 3OZL 3ESP 3I9I 3DJT 4TQP 2B77 4PWI 2F8I 2G4G 1III 1IIK 4ABW 1E4H 1FHN 3CN4 2WQA 3CN0 4PVL 3CN2 3CN3 2QEL 4IIZ 4QYA 1TLM 4ANK 3A4F 3CFT 3CFQ 3CFM 3CFN 1FH2 4L1S 2F7I 3SSG 3FCB 4QRF 1TSH 4PVM 2TRY 4KY2 3IMW 3TFB 4TQ8 4I89 3NEE 4IK7 2TRH 4HJT 4HJU 4HJS 4PWH
DrugBank ID DB00861 DB00451 DB00586 DB00279 DB01583 DB01093 DB00255
BioGrid ID 113127
GuidetoPHARMACOLOGY ID
PharmGKB ID PA37069
KEGG ID hsa:7276
BioCyc
Entrez Gene (Gene ID) 7276
DIP DIP-1083N
STRING 9606ENSP00000237014
MINT MINT-1374623
IntAct P02766
DMDM 136464
BREDNA
Rectome R-HSA-2453902 R-HSA-3000171 R-HSA-2453864 R-HSA-975634 R-HSA-977225
SignaLink
BindingDB P02766
  Model Performance Metrics
Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.769 0.772 0.757 0.804 0.709 0.800 0.779 0.786 0.800 0.769 Download
MACCS fingerprints 0.746 0.771 0.730 0.786 0.673 0.848 0.859 0.821 0.933 0.692 Download
Daylight fingerprints 0.661 0.691 0.667 0.643 0.691 0.667 0.649 0.643 0.667 0.615 Download
ECFP2 fingerprints 0.464 0.355 0.396 0.518 0.273 0.875 0.887 0.857 0.933 0.769 Download
ECFP4 fingerprints 0.688 0.611 0.649 0.768 0.527 0.824 0.872 0.786 0.933 0.615 Download
ECFP6 fingerprints 0.713 0.655 0.667 0.821 0.509 0.824 0.849 0.786 0.933 0.615 Download
  Download datasets
Positive dataset Negative dataset

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School of Pharmaceutical Sciences, Central South University. All rights reserved.
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