Details-Calcnet-AlzheimerNet

Target name

P03956: Interstitial collagenase

Protein function

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

Database links

Uniprot primary ID	P03956
PDB ID	1AYK 1CGE 4AYK 1CGF 1SU3 2CLT 2TCL 2J0T 1CGL 3SHI 1HFC 966C 2AYK 3AYK 4AUO
DrugBank ID	DB00786
BioGrid ID	110456
GuidetoPHARMACOLOGY ID	1628
PharmGKB ID	PA30867
KEGG ID
BioCyc
Entrez Gene (Gene ID)	4312
DIP	DIP-529N
STRING	9606ENSP00000322788
MINT	MINT-198818
IntAct	P03956
DMDM	116852
BREDNA	34247
Rectome	R-HSA-1592389 R-HSA-381426 R-HSA-1474228 R-HSA-210991 R-HSA-1442490
SignaLink
BindingDB	P03956

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.829	0.867	0.826	0.839	0.813	0.842	0.882	0.834	0.865	0.802	Download
MACCS fingerprints	0.817	0.878	0.813	0.832	0.793	0.819	0.894	0.817	0.843	0.792	Download
Daylight fingerprints	0.769	0.800	0.782	0.724	0.840	0.773	0.801	0.781	0.730	0.834	Download
ECFP2 fingerprints	0.862	0.929	0.856	0.899	0.813	0.874	0.942	0.867	0.904	0.828	Download
ECFP4 fingerprints	0.875	0.928	0.873	0.889	0.857	0.895	0.941	0.890	0.919	0.859	Download
ECFP6 fingerprints	0.872	0.923	0.871	0.875	0.867	0.890	0.937	0.886	0.901	0.871	Download

Download datasets

Positive dataset

Negative dataset