Details-Calcnet-AlzheimerNet

Target name

P04035: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Protein function

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Database links

Uniprot primary ID	P04035
PDB ID	1HW8 1HWL 2Q6B 1HWJ 1HWK 1HWI 2Q1L 3CD0 3CD7 3CD5 3CCW 3CCT 1DQA 1DQ8 1DQ9 3BGL 3CCZ 3CDB 3CDA 2Q6C 1HW9 2R4F
DrugBank ID	DB01076 DB01098 DB00641 DB01095 DB00227 DB00175 DB08860
BioGrid ID	109399
GuidetoPHARMACOLOGY ID	639
PharmGKB ID	PA189
KEGG ID	hsa:3156
BioCyc	MetaCyc:HS03652-MONOMER
Entrez Gene (Gene ID)	3156
DIP
STRING	9606ENSP00000287936
MINT
IntAct	P04035
DMDM	123343
BREDNA	11134
Rectome	R-HSA-1989781 R-HSA-191273 R-HSA-2426168
SignaLink
BindingDB	P04035

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.880	0.928	0.887	0.830	0.945	0.925	0.945	0.912	0.891	0.944	Download
MACCS fingerprints	0.890	0.957	0.887	0.931	0.845	0.936	0.986	0.921	0.927	0.912	Download
Daylight fingerprints	0.817	0.838	0.832	0.747	0.918	0.824	0.821	0.802	0.764	0.861	Download
ECFP2 fingerprints	0.861	0.953	0.868	0.819	0.918	0.923	0.969	0.912	0.873	0.972	Download
ECFP4 fingerprints	0.876	0.961	0.882	0.835	0.929	0.933	0.967	0.923	0.891	0.972	Download
ECFP6 fingerprints	0.896	0.921	0.901	0.852	0.951	0.933	0.955	0.923	0.891	0.972	Download

Download datasets

Positive dataset

Negative dataset