Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (PubMed:
| Uniprot primary ID | P04156 |
| PDB ID | 1QLZ 1QLX 1H0L 2LFT 2LSB 1QM1 1QM0 1QM3 1QM2 1HJM 1HJN 1E1G 4E1H 1FO7 2LBG 2M8T 2K1D 3HJX 2LV1 1OEI 1OEH 3NHC 1E1U 1E1W 2KUN 1E1P 1E1S 2IV5 2IV4 2IV6 3HAF 1E1J 3MD4 3MD5 3HJ5 1FKC 2W9E 4DGI 4KML 4N9O 3NHD 2OL9 1I4M 2LEJ 4E1I 3HAK 3HER 3HES 3HEQ 3NVF |
| DrugBank ID | DB00759 |
| BioGrid ID | 111606 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA33796 |
| KEGG ID | hsa:5621 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5621 |
| DIP | DIP-29933N |
| STRING | 9606ENSP00000368752 |
| MINT | MINT-1420984 |
| IntAct | P04156 |
| DMDM | 130912 |
| BREDNA | |
| Rectome | R-HSA-419037 |
| SignaLink | |
| BindingDB | P04156 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.731 | 0.831 | 0.754 | 0.668 | 0.840 | 0.747 | 0.810 | 0.766 | 0.685 | 0.849 | Download |
| MACCS fingerprints | 0.775 | 0.829 | 0.778 | 0.766 | 0.789 | 0.760 | 0.835 | 0.776 | 0.704 | 0.849 | Download |
| Daylight fingerprints | 0.689 | 0.723 | 0.714 | 0.631 | 0.798 | 0.720 | 0.752 | 0.738 | 0.667 | 0.811 | Download |
| ECFP2 fingerprints | 0.755 | 0.814 | 0.745 | 0.785 | 0.704 | 0.792 | 0.881 | 0.794 | 0.778 | 0.811 | Download |
| ECFP4 fingerprints | 0.799 | 0.855 | 0.794 | 0.818 | 0.770 | 0.796 | 0.889 | 0.804 | 0.759 | 0.849 | Download |
| ECFP6 fingerprints | 0.763 | 0.862 | 0.770 | 0.738 | 0.803 | 0.762 | 0.869 | 0.766 | 0.741 | 0.792 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
All rights reserved.
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E-mail: biomed@csu.edu.cn
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