Details-Calcnet-AlzheimerNet

Target name

P05121: Plasminogen activator inhibitor 1

Protein function

Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

Database links

Uniprot primary ID	P05121
PDB ID	4IC0 3CVM 3Q03 1DB2 1A7C 3UT3 1C5G 4G8R 3Q02 3EOX 4G8O 1OC0 9PAI 1DVN 1LJ5 3PB1 3R4L 1B3K 1DVM 4AQH
DrugBank ID	DB00031 DB00055 DB00009 DB00013 DB00029 DB00015
BioGrid ID	111091
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA261
KEGG ID	hsa:5054
BioCyc
Entrez Gene (Gene ID)	5054
DIP
STRING	9606ENSP00000223095
MINT	MINT-202409
IntAct	P05121
DMDM	129576
BREDNA
Rectome	R-HSA-3000178 R-HSA-75205 R-HSA-1368108 R-HSA-114608 R-HSA-2173796
SignaLink
BindingDB	P05121

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.722	0.773	0.738	0.679	0.798	0.887	0.879	0.869	0.915	0.811	Download
MACCS fingerprints	0.754	0.728	0.737	0.804	0.671	0.786	0.838	0.786	0.825	0.750	Download
Daylight fingerprints	0.738	0.756	0.747	0.714	0.780	0.842	0.813	0.821	0.851	0.784	Download
ECFP2 fingerprints	0.653	0.683	0.655	0.649	0.661	0.898	0.904	0.881	0.936	0.811	Download
ECFP4 fingerprints	0.727	0.759	0.738	0.696	0.780	0.896	0.913	0.881	0.915	0.838	Download
ECFP6 fingerprints	0.726	0.776	0.741	0.685	0.798	0.872	0.922	0.857	0.872	0.838	Download

Download datasets

Positive dataset

Negative dataset