Details-Calcnet-AlzheimerNet

Target name

P05164: Myeloperoxidase

Protein function

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Database links

Uniprot primary ID	P05164
PDB ID	1D7W 1CXP 4C1M 1DNU 1D5L 1DNW 1D2V 3F9P 4DL1 3ZS0 3ZS1 1MYP 1MHL 4EJX
DrugBank ID	DB00104 DB01065 DB00461 DB00958 DB00847 DB00515 DB00208 DB00535 DB00833 DB00526 DB00062 DB01225 DB00250 DB00550 DB00233 DB00583 DB00244 DB02300 DB00006 DB00500
BioGrid ID	110493
GuidetoPHARMACOLOGY ID	2789
PharmGKB ID	PA243
KEGG ID	hsa:4353
BioCyc	MetaCyc:HS00140-MONOMER
Entrez Gene (Gene ID)	4353
DIP
STRING	9606ENSP00000225275
MINT	MINT-1522833
IntAct	P05164
DMDM	129825
BREDNA	11122
Rectome
SignaLink
BindingDB	P05164

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.824	0.862	0.830	0.792	0.868	0.889	0.936	0.897	0.941	0.864	Download
MACCS fingerprints	0.700	0.811	0.725	0.636	0.816	0.722	0.860	0.744	0.765	0.727	Download
Daylight fingerprints	0.765	0.771	0.771	0.740	0.803	0.889	0.902	0.897	0.941	0.864	Download
ECFP2 fingerprints	0.723	0.826	0.719	0.727	0.711	0.778	0.947	0.795	0.824	0.773	Download
ECFP4 fingerprints	0.781	0.870	0.784	0.766	0.803	0.895	0.965	0.897	1.000	0.818	Download
ECFP6 fingerprints	0.797	0.882	0.804	0.766	0.842	0.914	0.979	0.923	0.941	0.909	Download

Download datasets

Positive dataset

Negative dataset