Target name

P05164: Myeloperoxidase


  Protein function

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

  Database links

Uniprot primary ID P05164
PDB ID 1D7W 1CXP 4C1M 1DNU 1D5L 1DNW 1D2V 3F9P 4DL1 3ZS0 3ZS1 1MYP 1MHL 4EJX
DrugBank ID DB00104 DB01065 DB00461 DB00958 DB00847 DB00515 DB00208 DB00535 DB00833 DB00526 DB00062 DB01225 DB00250 DB00550 DB00233 DB00583 DB00244 DB02300 DB00006 DB00500
BioGrid ID 110493
GuidetoPHARMACOLOGY ID 2789
PharmGKB ID PA243
KEGG ID hsa:4353
BioCyc MetaCyc:HS00140-MONOMER
Entrez Gene (Gene ID) 4353
DIP
STRING 9606ENSP00000225275
MINT MINT-1522833
IntAct P05164
DMDM 129825
BREDNA 11122
Rectome
SignaLink
BindingDB P05164

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.824 0.862 0.830 0.792 0.868 0.889 0.936 0.897 0.941 0.864 Download
MACCS fingerprints 0.700 0.811 0.725 0.636 0.816 0.722 0.860 0.744 0.765 0.727 Download
Daylight fingerprints 0.765 0.771 0.771 0.740 0.803 0.889 0.902 0.897 0.941 0.864 Download
ECFP2 fingerprints 0.723 0.826 0.719 0.727 0.711 0.778 0.947 0.795 0.824 0.773 Download
ECFP4 fingerprints 0.781 0.870 0.784 0.766 0.803 0.895 0.965 0.897 1.000 0.818 Download
ECFP6 fingerprints 0.797 0.882 0.804 0.766 0.842 0.914 0.979 0.923 0.941 0.909 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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