Details-Calcnet-AlzheimerNet

Target name

P05362: Intercellular adhesion molecule 1

Protein function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Database links

Uniprot primary ID	P05362
PDB ID	2OZ4 1IAM 1D3L 1D3I 3TCX 1IC1 1D3E 1P53 1Z7Z 1IJ4 1MQ8
DrugBank ID	DB08818 DB00108
BioGrid ID	109610
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA29592
KEGG ID	hsa:3383
BioCyc
Entrez Gene (Gene ID)	3383
DIP	DIP-36658N
STRING	9606ENSP00000264832
MINT	MINT-4053071
IntAct	P05362
DMDM	68067956
BREDNA
Rectome	R-HSA-216083 R-HSA-877300 R-HSA-198933
SignaLink
BindingDB	P05362

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.809	0.846	0.828	0.729	0.928	0.896	0.920	0.894	0.845	0.952	Download
MACCS fingerprints	0.745	0.780	0.763	0.693	0.833	0.760	0.852	0.761	0.701	0.831	Download
Daylight fingerprints	0.752	0.795	0.792	0.632	0.953	0.793	0.848	0.811	0.670	0.976	Download
ECFP2 fingerprints	0.834	0.878	0.844	0.781	0.908	0.883	0.933	0.878	0.856	0.904	Download
ECFP4 fingerprints	0.861	0.899	0.868	0.814	0.922	0.899	0.935	0.894	0.876	0.916	Download
ECFP6 fingerprints	0.856	0.895	0.864	0.806	0.922	0.899	0.923	0.894	0.876	0.916	Download

Download datasets

Positive dataset

Negative dataset