Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
| Uniprot primary ID | P07339 |
| PDB ID | 1LYA 1LYB 4OBZ 4OC6 4OD9 1LYW |
| DrugBank ID | DB00030 |
| BioGrid ID | 107889 |
| GuidetoPHARMACOLOGY ID | 2345 |
| PharmGKB ID | PA27029 |
| KEGG ID | hsa:1509 |
| BioCyc | MetaCyc:HS04183-MONOMER |
| Entrez Gene (Gene ID) | 1509 |
| DIP | DIP-43906N |
| STRING | 9606ENSP00000236671 |
| MINT | MINT-3005628 |
| IntAct | P07339 |
| DMDM | 115717 |
| BREDNA | 34235 |
| Rectome | R-HSA-1442490 R-HSA-2022377 R-HSA-2132295 |
| SignaLink | |
| BindingDB | P07339 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.830 | 0.866 | 0.830 | 0.828 | 0.831 | 0.814 | 0.854 | 0.824 | 0.818 | 0.830 | Download |
| MACCS fingerprints | 0.795 | 0.844 | 0.796 | 0.785 | 0.808 | 0.772 | 0.842 | 0.786 | 0.768 | 0.802 | Download |
| Daylight fingerprints | 0.829 | 0.842 | 0.830 | 0.821 | 0.839 | 0.830 | 0.848 | 0.842 | 0.823 | 0.858 | Download |
| ECFP2 fingerprints | 0.819 | 0.890 | 0.826 | 0.785 | 0.867 | 0.804 | 0.909 | 0.822 | 0.773 | 0.866 | Download |
| ECFP4 fingerprints | 0.838 | 0.895 | 0.846 | 0.793 | 0.899 | 0.820 | 0.888 | 0.839 | 0.777 | 0.895 | Download |
| ECFP6 fingerprints | 0.837 | 0.880 | 0.846 | 0.787 | 0.906 | 0.818 | 0.886 | 0.837 | 0.777 | 0.891 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
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