Target name

P07384: Calpain-1 catalytic subunit


  Protein function

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

  Database links

Uniprot primary ID P07384
PDB ID 2ARY 1ZCM
DrugBank ID
BioGrid ID 107273
GuidetoPHARMACOLOGY ID
PharmGKB ID PA26057
KEGG ID hsa:823
BioCyc
Entrez Gene (Gene ID) 823
DIP
STRING 9606ENSP00000279247
MINT MINT-5004023
IntAct P07384
DMDM 115574
BREDNA 342252 342253
Rectome R-HSA-1474228
SignaLink
BindingDB P07384

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.847 0.895 0.844 0.863 0.825 0.882 0.910 0.875 0.932 0.820 Download
MACCS fingerprints 0.874 0.913 0.870 0.898 0.841 0.888 0.924 0.883 0.932 0.835 Download
Daylight fingerprints 0.820 0.838 0.827 0.783 0.871 0.881 0.892 0.879 0.894 0.865 Download
ECFP2 fingerprints 0.912 0.940 0.908 0.944 0.873 0.926 0.949 0.925 0.947 0.902 Download
ECFP4 fingerprints 0.927 0.942 0.925 0.942 0.909 0.933 0.950 0.932 0.955 0.910 Download
ECFP6 fingerprints 0.921 0.941 0.921 0.928 0.913 0.940 0.947 0.940 0.955 0.925 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn