Details-Calcnet-AlzheimerNet

Target name

P07550: Beta-2 adrenergic receptor

Protein function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Database links

Uniprot primary ID	P07550
PDB ID	3P0G 3KJ6 3NY8 3NY9 3PDS 1GQ4 3SN6 4GBR 3NYA 4LDL 3D4S 4LDO 4QKX 2RH1 4LDE 2R4R 2R4S
DrugBank ID	DB01288 DB01064 DB00598 DB08808 DB00221 DB01102 DB08807 DB00321 DB00938 DB00816 DB06262 DB01193 DB00449 DB00871 DB01214 DB04861 DB00521 DB00852 DB00373 DB01407 DB00370 DB01136 DB00540 DB00612 DB01408 DB01363 DB00925 DB01151 DB00489 DB00960 DB00334 DB00867
BioGrid ID	106663
GuidetoPHARMACOLOGY ID	29
PharmGKB ID	PA39
KEGG ID	hsa:154
BioCyc
Entrez Gene (Gene ID)	154
DIP	DIP-33948N
STRING	9606ENSP00000305372
MINT	MINT-148142
IntAct	P07550
DMDM	296439450
BREDNA
Rectome	R-HSA-418555 R-HSA-390696
SignaLink	P07550
BindingDB	P07550

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.886	0.920	0.885	0.888	0.882	0.892	0.916	0.892	0.913	0.872	Download
MACCS fingerprints	0.753	0.890	0.774	0.689	0.858	0.740	0.886	0.765	0.683	0.844	Download
Daylight fingerprints	0.853	0.870	0.859	0.813	0.906	0.842	0.865	0.850	0.817	0.881	Download
ECFP2 fingerprints	0.910	0.932	0.908	0.925	0.892	0.907	0.923	0.906	0.942	0.872	Download
ECFP4 fingerprints	0.915	0.934	0.913	0.927	0.899	0.917	0.916	0.915	0.962	0.872	Download
ECFP6 fingerprints	0.900	0.926	0.900	0.897	0.904	0.897	0.916	0.897	0.923	0.872	Download

Download datasets

Positive dataset

Negative dataset