Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.
| Uniprot primary ID | P08253 |
| PDB ID | 1GEN 1CK7 1CXW 1KS0 1RTG 1HOV 1EAK 1QIB 1GXD 3AYU 1J7M |
| DrugBank ID | DB00786 DB01197 |
| BioGrid ID | 110457 |
| GuidetoPHARMACOLOGY ID | 1629 |
| PharmGKB ID | PA30877 |
| KEGG ID | hsa:4313 |
| BioCyc | MetaCyc:HS01565-MONOMER |
| Entrez Gene (Gene ID) | 4313 |
| DIP | DIP-26N |
| STRING | 9606ENSP00000219070 |
| MINT | |
| IntAct | P08253 |
| DMDM | 116856 |
| BREDNA | 342424 |
| Rectome | R-HSA-1592389 R-HSA-381426 R-HSA-3928665 R-HSA-1474228 R-HSA-1442490 |
| SignaLink | |
| BindingDB | P08253 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.826 | 0.888 | 0.823 | 0.837 | 0.810 | 0.864 | 0.923 | 0.861 | 0.855 | 0.868 | Download |
| MACCS fingerprints | 0.794 | 0.873 | 0.796 | 0.789 | 0.803 | 0.797 | 0.869 | 0.794 | 0.785 | 0.803 | Download |
| Daylight fingerprints | 0.793 | 0.834 | 0.805 | 0.744 | 0.868 | 0.825 | 0.856 | 0.832 | 0.787 | 0.877 | Download |
| ECFP2 fingerprints | 0.857 | 0.933 | 0.854 | 0.875 | 0.833 | 0.883 | 0.955 | 0.879 | 0.907 | 0.850 | Download |
| ECFP4 fingerprints | 0.877 | 0.943 | 0.877 | 0.876 | 0.878 | 0.899 | 0.964 | 0.898 | 0.902 | 0.894 | Download |
| ECFP6 fingerprints | 0.870 | 0.940 | 0.873 | 0.852 | 0.894 | 0.906 | 0.961 | 0.906 | 0.901 | 0.911 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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