Details-Calcnet-AlzheimerNet

Target name

P08311: Cathepsin G

Protein function

Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

Database links

Uniprot primary ID	P08311
PDB ID	1CGH 1T32 1AU8 1KYN
DrugBank ID
BioGrid ID	107891
GuidetoPHARMACOLOGY ID	2348
PharmGKB ID	PA27032
KEGG ID	hsa:1511
BioCyc
Entrez Gene (Gene ID)	1511
DIP
STRING	9606ENSP00000216336
MINT	MINT-4054534
IntAct	P08311
DMDM	115725
BREDNA	342120
Rectome	R-HSA-1592389 R-HSA-381426 R-HSA-2022377 R-HSA-1474228
SignaLink
BindingDB	P08311

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.590	0.651	0.591	0.583	0.600	0.651	0.719	0.642	0.659	0.625	Download
MACCS fingerprints	0.622	0.600	0.593	0.667	0.519	0.612	0.655	0.593	0.634	0.550	Download
Daylight fingerprints	0.632	0.626	0.601	0.681	0.519	0.753	0.788	0.741	0.780	0.700	Download
ECFP2 fingerprints	0.454	0.497	0.471	0.436	0.506	0.667	0.797	0.679	0.634	0.725	Download
ECFP4 fingerprints	0.640	0.701	0.638	0.638	0.638	0.750	0.831	0.753	0.732	0.775	Download
ECFP6 fingerprints	0.652	0.735	0.656	0.638	0.675	0.765	0.827	0.765	0.756	0.775	Download

Download datasets

Positive dataset

Negative dataset