G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca
| Uniprot primary ID | P08908 |
| PDB ID | |
| DrugBank ID | DB00952 DB06148 DB01142 DB01049 DB08807 DB01622 DB00321 DB00490 DB01621 DB04946 DB01359 DB01238 DB00216 DB00408 DB00540 DB00960 DB00543 DB01616 DB01614 DB01151 DB00669 DB06216 DB08810 DB00334 DB05271 DB00726 DB08815 DB01149 DB00904 DB01392 DB01267 DB00246 |
| BioGrid ID | 109582 |
| GuidetoPHARMACOLOGY ID | 1 |
| PharmGKB ID | PA192 |
| KEGG ID | hsa:3350 |
| BioCyc | |
| Entrez Gene (Gene ID) | 3350 |
| DIP | |
| STRING | 9606ENSP00000316244 |
| MINT | |
| IntAct | P08908 |
| DMDM | 231454 |
| BREDNA | |
| Rectome | R-HSA-418594 R-HSA-390666 |
| SignaLink | |
| BindingDB | P08908 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.797 | 0.868 | 0.796 | 0.799 | 0.794 | 0.808 | 0.883 | 0.808 | 0.805 | 0.811 | Download |
| MACCS fingerprints | 0.763 | 0.824 | 0.750 | 0.803 | 0.697 | 0.780 | 0.844 | 0.767 | 0.824 | 0.708 | Download |
| Daylight fingerprints | 0.758 | 0.823 | 0.775 | 0.702 | 0.849 | 0.770 | 0.833 | 0.785 | 0.716 | 0.854 | Download |
| ECFP2 fingerprints | 0.855 | 0.930 | 0.850 | 0.879 | 0.821 | 0.861 | 0.940 | 0.857 | 0.886 | 0.828 | Download |
| ECFP4 fingerprints | 0.874 | 0.942 | 0.875 | 0.860 | 0.890 | 0.876 | 0.948 | 0.877 | 0.865 | 0.890 | Download |
| ECFP6 fingerprints | 0.860 | 0.936 | 0.865 | 0.825 | 0.906 | 0.870 | 0.943 | 0.875 | 0.837 | 0.913 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
All rights reserved.
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