Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
| Uniprot primary ID | P09917 |
| PDB ID | 3V98 3V99 3V92 3O8Y 2ABV |
| DrugBank ID | DB00471 DB01014 DB00795 DB00744 DB00586 DB00939 DB00163 DB01017 DB00711 DB00233 DB00244 DB00179 |
| BioGrid ID | 106741 |
| GuidetoPHARMACOLOGY ID | 1385 |
| PharmGKB ID | PA46 |
| KEGG ID | hsa:240 |
| BioCyc | MetaCyc:HS00336-MONOMER |
| Entrez Gene (Gene ID) | 240 |
| DIP | DIP-30950N |
| STRING | 9606ENSP00000363512 |
| MINT | |
| IntAct | P09917 |
| DMDM | 126407 |
| BREDNA | 1131134 |
| Rectome | R-HSA-2142691 R-HSA-2142688 R-HSA-2142700 |
| SignaLink | |
| BindingDB | P09917 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.757 | 0.827 | 0.764 | 0.734 | 0.795 | 0.808 | 0.876 | 0.815 | 0.781 | 0.848 | Download |
| MACCS fingerprints | 0.745 | 0.788 | 0.744 | 0.747 | 0.740 | 0.741 | 0.798 | 0.747 | 0.728 | 0.766 | Download |
| Daylight fingerprints | 0.671 | 0.704 | 0.675 | 0.659 | 0.691 | 0.752 | 0.795 | 0.744 | 0.776 | 0.713 | Download |
| ECFP2 fingerprints | 0.816 | 0.908 | 0.817 | 0.812 | 0.821 | 0.871 | 0.946 | 0.870 | 0.875 | 0.865 | Download |
| ECFP4 fingerprints | 0.826 | 0.923 | 0.833 | 0.792 | 0.874 | 0.886 | 0.960 | 0.888 | 0.873 | 0.904 | Download |
| ECFP6 fingerprints | 0.811 | 0.908 | 0.826 | 0.743 | 0.908 | 0.860 | 0.948 | 0.869 | 0.806 | 0.931 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
All rights reserved.
The recommended browsers: Safari, Firefox, Chrome,IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |