Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
| Uniprot primary ID | P10275 |
| PDB ID | 2OZ7 2AX8 3B65 2PNU 3B67 3B66 3B68 4OKX 3V4A 3RLL 4OKB 4OIL 2PIV 1Z95 3ZQT 4OKW 4OH6 4OH5 2HVC 2AX7 2AM9 1XQ3 2Q7J 2Q7K 2AX9 2Q7I 2AO6 2Q7L 2YHD 4OEA 4OED 2YLQ 2YLP 3L3X 3B5R 1GS4 2Z4J 2PIU 2PIT 2PIW 2PKL 2PIQ 2PIP 2PIR 2PIX 4OGH 4OLM 4OJ9 1T63 4OJB 3V49 |
| DrugBank ID | DB00984 DB00687 DB01185 DB00858 DB00499 DB08804 DB01395 DB01420 DB04839 DB01026 DB01406 DB00624 DB06710 DB00621 DB00367 DB00665 DB08899 DB01128 DB00421 |
| BioGrid ID | 106862 |
| GuidetoPHARMACOLOGY ID | 628 |
| PharmGKB ID | PA57 |
| KEGG ID | hsa:367 |
| BioCyc | |
| Entrez Gene (Gene ID) | 367 |
| DIP | DIP-125N |
| STRING | 9606ENSP00000363822 |
| MINT | MINT-94801 |
| IntAct | P10275 |
| DMDM | 113830 |
| BREDNA | |
| Rectome | R-HSA-383280 R-HSA-5625886 |
| SignaLink | P10275 |
| BindingDB | P10275 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.825 | 0.907 | 0.831 | 0.798 | 0.863 | 0.848 | 0.928 | 0.851 | 0.825 | 0.878 | Download |
| MACCS fingerprints | 0.816 | 0.863 | 0.811 | 0.834 | 0.788 | 0.813 | 0.866 | 0.806 | 0.834 | 0.778 | Download |
| Daylight fingerprints | 0.728 | 0.796 | 0.759 | 0.643 | 0.875 | 0.735 | 0.810 | 0.763 | 0.652 | 0.875 | Download |
| ECFP2 fingerprints | 0.909 | 0.968 | 0.911 | 0.892 | 0.930 | 0.920 | 0.976 | 0.921 | 0.914 | 0.927 | Download |
| ECFP4 fingerprints | 0.913 | 0.967 | 0.917 | 0.870 | 0.964 | 0.935 | 0.975 | 0.936 | 0.902 | 0.971 | Download |
| ECFP6 fingerprints | 0.898 | 0.960 | 0.902 | 0.852 | 0.954 | 0.916 | 0.968 | 0.919 | 0.882 | 0.956 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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