Details-Calcnet-AlzheimerNet

Target name

P11229: Muscarinic acetylcholine receptor M1

Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Database links

Uniprot primary ID	P11229
PDB ID
DrugBank ID	DB00777 DB00979 DB01142 DB00771 DB00496 DB00321 DB00670 DB01148 DB00810 DB00568 DB04843 DB00280 DB00387 DB00934 DB01069 DB00875 DB01239 DB01238 DB00508 DB01231 DB00835 DB01233 DB00785 DB00408 DB00420 DB00219 DB00747 DB00726 DB00202 DB00458 DB01221 DB00782
BioGrid ID	107550
GuidetoPHARMACOLOGY ID	13
PharmGKB ID	PA26484
KEGG ID	hsa:1128
BioCyc
Entrez Gene (Gene ID)	1128
DIP
STRING	9606ENSP00000306490
MINT	MINT-7970464
IntAct	P11229
DMDM	113118
BREDNA
Rectome	R-HSA-390648 R-HSA-416476
SignaLink
BindingDB	P11229

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.778	0.817	0.773	0.804	0.742	0.809	0.837	0.800	0.827	0.772	Download
MACCS fingerprints	0.782	0.834	0.762	0.864	0.662	0.794	0.839	0.763	0.877	0.638	Download
Daylight fingerprints	0.718	0.728	0.706	0.757	0.655	0.761	0.760	0.748	0.804	0.693	Download
ECFP2 fingerprints	0.819	0.908	0.823	0.806	0.839	0.836	0.933	0.839	0.825	0.853	Download
ECFP4 fingerprints	0.829	0.921	0.840	0.781	0.899	0.887	0.956	0.890	0.866	0.913	Download
ECFP6 fingerprints	0.816	0.910	0.834	0.743	0.924	0.855	0.951	0.866	0.795	0.936	Download

Download datasets

Positive dataset

Negative dataset