Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
| Uniprot primary ID | P11473 |
| PDB ID | 3AZ2 3A78 3AZ1 2HAS 2HAR 3W0C 3W0A 3AX8 3W0Y 2HAM 4PA2 3OGT 1DB1 1YNW 4G2I 3CS6 3CS4 1KB2 1IE9 1TXI 1KB6 1KB4 2HB8 3P8X 3M7R 2HB7 3A40 3AUR 3AUQ 3TKC 1S0Z 3A2I 3A2J 4ITF 3AZ3 1IE8 3WWR 3KPZ 1S19 3A3Z 3B0T 4ITE 3WGP 3VHW |
| DrugBank ID | DB00136 DB00153 DB01436 DB01070 DB00146 DB02300 DB00169 DB00910 |
| BioGrid ID | 113264 |
| GuidetoPHARMACOLOGY ID | 605 |
| PharmGKB ID | PA37301 |
| KEGG ID | hsa:7421 |
| BioCyc | |
| Entrez Gene (Gene ID) | 7421 |
| DIP | DIP-32624N |
| STRING | 9606ENSP00000447173 |
| MINT | MINT-236408 |
| IntAct | P11473 |
| DMDM | 137617 |
| BREDNA | |
| Rectome | R-HSA-383280 |
| SignaLink | P11473 |
| BindingDB | P11473 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.776 | 0.831 | 0.811 | 0.718 | 0.889 | 0.833 | 0.864 | 0.868 | 0.741 | 0.970 | Download |
| MACCS fingerprints | 0.821 | 0.900 | 0.840 | 0.805 | 0.870 | 0.882 | 0.920 | 0.901 | 0.833 | 0.955 | Download |
| Daylight fingerprints | 0.759 | 0.793 | 0.803 | 0.682 | 0.905 | 0.766 | 0.808 | 0.818 | 0.667 | 0.940 | Download |
| ECFP2 fingerprints | 0.766 | 0.862 | 0.822 | 0.641 | 0.973 | 0.804 | 0.923 | 0.851 | 0.685 | 0.985 | Download |
| ECFP4 fingerprints | 0.804 | 0.874 | 0.846 | 0.691 | 0.977 | 0.817 | 0.893 | 0.860 | 0.704 | 0.985 | Download |
| ECFP6 fingerprints | 0.807 | 0.867 | 0.849 | 0.695 | 0.977 | 0.826 | 0.884 | 0.868 | 0.704 | 1.000 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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