Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
| Uniprot primary ID | P12821 |
| PDB ID | 1O8A 3NXQ 4BXK 2C6N 2OC2 4BZR 4BZS 2C6F 1UZF 4APJ 2XYD 4C2O 3L3N 2YDM 3BKK 2IUX 3BKL 4C2N 2IUL 4C2Q 4C2P 4C2R 1UZE 4CA5 4CA6 2XY9 1O86 4APH |
| DrugBank ID | DB00691 DB01180 DB01348 DB01197 DB00492 DB00722 DB00584 DB01340 DB00616 DB00790 DB00178 DB00881 DB00519 DB00542 |
| BioGrid ID | 108004 |
| GuidetoPHARMACOLOGY ID | 1613 |
| PharmGKB ID | PA139 |
| KEGG ID | hsa:1636 |
| BioCyc | MetaCyc:HS08412-MONOMER |
| Entrez Gene (Gene ID) | 1636 |
| DIP | |
| STRING | 9606ENSP00000290866 |
| MINT | MINT-127316 |
| IntAct | P12821 |
| DMDM | 113045 |
| BREDNA | 34151 |
| Rectome | R-HSA-2022377 |
| SignaLink | P12821 |
| BindingDB | P12821 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.881 | 0.896 | 0.874 | 0.934 | 0.813 | 0.903 | 0.920 | 0.902 | 0.944 | 0.864 | Download |
| MACCS fingerprints | 0.895 | 0.901 | 0.886 | 0.967 | 0.805 | 0.908 | 0.923 | 0.906 | 0.975 | 0.844 | Download |
| Daylight fingerprints | 0.876 | 0.879 | 0.873 | 0.893 | 0.853 | 0.882 | 0.900 | 0.887 | 0.871 | 0.902 | Download |
| ECFP2 fingerprints | 0.901 | 0.952 | 0.891 | 0.981 | 0.802 | 0.921 | 0.970 | 0.918 | 0.992 | 0.848 | Download |
| ECFP4 fingerprints | 0.907 | 0.939 | 0.899 | 0.975 | 0.823 | 0.928 | 0.974 | 0.926 | 0.992 | 0.864 | Download |
| ECFP6 fingerprints | 0.903 | 0.935 | 0.898 | 0.947 | 0.849 | 0.938 | 0.969 | 0.938 | 0.984 | 0.894 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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