Details-Calcnet-AlzheimerNet

Target name

P13569: Cystic fibrosis transmembrane conductance regulator

Protein function

Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

Database links

Uniprot primary ID	P13569
PDB ID	2LOB 1XMI 2BBT 2BBS 2BBO 1XMJ 3GD7 2PZE 3ISW 2PZG 2PZF 1NBD
DrugBank ID	DB01050 DB00887 DB08820 DB01016 DB04941
BioGrid ID	107506
GuidetoPHARMACOLOGY ID	707
PharmGKB ID	PA109
KEGG ID	hsa:1080
BioCyc	MetaCyc:HS00075-MONOMER
Entrez Gene (Gene ID)	1080
DIP	DIP-32788N
STRING	9606ENSP00000003084
MINT	MINT-148539
IntAct	P13569
DMDM	147744553
BREDNA	36349
Rectome	R-HSA-382556 R-HSA-5627083 R-HSA-5678895
SignaLink
BindingDB	P13569

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.871	0.887	0.883	0.786	0.982	0.811	0.841	0.875	0.682	1.000	Download
MACCS fingerprints	0.852	0.917	0.860	0.802	0.919	0.791	0.874	0.839	0.773	0.882	Download
Daylight fingerprints	0.874	0.883	0.883	0.811	0.955	0.850	0.868	0.893	0.773	0.971	Download
ECFP2 fingerprints	0.863	0.846	0.874	0.793	0.955	0.821	0.919	0.875	0.727	0.971	Download
ECFP4 fingerprints	0.880	0.875	0.892	0.793	0.991	0.821	0.892	0.875	0.727	0.971	Download
ECFP6 fingerprints	0.880	0.898	0.892	0.793	0.991	0.821	0.871	0.875	0.727	0.971	Download

Download datasets

Positive dataset

Negative dataset