Details-Calcnet-AlzheimerNet

Target name

P14555: Phospholipase A2, membrane associated

Protein function

Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Database links

Uniprot primary ID	P14555
PDB ID	1DB5 1DB4 2GNY 1J1A 1POD 3U8H 1DCY 1KVO 3U8B 1POE 1BBC 1AYP 3U8I 1N28 3U8D 1N29 1KQU
DrugBank ID	DB01381 DB04786 DB00328 DB00586
BioGrid ID	111337
GuidetoPHARMACOLOGY ID	1417
PharmGKB ID	PA270
KEGG ID	hsa:5320
BioCyc
Entrez Gene (Gene ID)	5320
DIP
STRING	9606ENSP00000364252
MINT	MINT-1206447
IntAct	P14555
DMDM	129483
BREDNA	3114
Rectome	R-HSA-1483166 R-HSA-1482839 R-HSA-1482801 R-HSA-1482925 R-HSA-1482922 R-HSA-1482788
SignaLink
BindingDB	P14555

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.766	0.811	0.779	0.724	0.834	0.845	0.848	0.841	0.819	0.865	Download
MACCS fingerprints	0.781	0.857	0.780	0.782	0.779	0.849	0.905	0.833	0.890	0.770	Download
Daylight fingerprints	0.766	0.787	0.786	0.702	0.869	0.831	0.843	0.834	0.771	0.905	Download
ECFP2 fingerprints	0.778	0.866	0.784	0.760	0.808	0.881	0.947	0.873	0.892	0.851	Download
ECFP4 fingerprints	0.788	0.872	0.790	0.779	0.802	0.890	0.936	0.879	0.928	0.824	Download
ECFP6 fingerprints	0.801	0.864	0.805	0.788	0.821	0.885	0.917	0.879	0.880	0.878	Download

Download datasets

Positive dataset

Negative dataset