May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
| Uniprot primary ID | P14780 |
| PDB ID | 2OW0 1LKG 1GKC 2OVX 1GKD 2OW1 2OVZ 4H2E 2OW2 1L6J 4H3X 4H1Q 4HMA 4H82 4JIJ 1ITV 4XCT 4JQG |
| DrugBank ID | DB01017 DB00786 DB01296 DB01197 |
| BioGrid ID | 110461 |
| GuidetoPHARMACOLOGY ID | 1633 |
| PharmGKB ID | PA30889 |
| KEGG ID | hsa:4318 |
| BioCyc | |
| Entrez Gene (Gene ID) | 4318 |
| DIP | DIP-29518N |
| STRING | 9606ENSP00000361405 |
| MINT | MINT-7709677 |
| IntAct | P14780 |
| DMDM | 269849668 |
| BREDNA | 342435 |
| Rectome | R-HSA-1433557 R-HSA-3928665 R-HSA-1474228 R-HSA-1442490 R-HSA-1592389 R-HSA-2022090 |
| SignaLink | |
| BindingDB | P14780 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.868 | 0.917 | 0.866 | 0.873 | 0.859 | 0.867 | 0.914 | 0.863 | 0.881 | 0.845 | Download |
| MACCS fingerprints | 0.792 | 0.887 | 0.798 | 0.766 | 0.831 | 0.800 | 0.904 | 0.803 | 0.764 | 0.845 | Download |
| Daylight fingerprints | 0.821 | 0.847 | 0.830 | 0.777 | 0.883 | 0.856 | 0.884 | 0.860 | 0.825 | 0.895 | Download |
| ECFP2 fingerprints | 0.900 | 0.950 | 0.897 | 0.923 | 0.871 | 0.917 | 0.961 | 0.912 | 0.960 | 0.861 | Download |
| ECFP4 fingerprints | 0.926 | 0.959 | 0.924 | 0.946 | 0.902 | 0.927 | 0.965 | 0.923 | 0.957 | 0.889 | Download |
| ECFP6 fingerprints | 0.919 | 0.958 | 0.918 | 0.920 | 0.916 | 0.927 | 0.965 | 0.925 | 0.937 | 0.912 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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