Target name

P14780: Matrix metalloproteinase-9


  Protein function

May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

  Database links

Uniprot primary ID P14780
PDB ID 2OW0 1LKG 1GKC 2OVX 1GKD 2OW1 2OVZ 4H2E 2OW2 1L6J 4H3X 4H1Q 4HMA 4H82 4JIJ 1ITV 4XCT 4JQG
DrugBank ID DB01017 DB00786 DB01296 DB01197
BioGrid ID 110461
GuidetoPHARMACOLOGY ID 1633
PharmGKB ID PA30889
KEGG ID hsa:4318
BioCyc
Entrez Gene (Gene ID) 4318
DIP DIP-29518N
STRING 9606ENSP00000361405
MINT MINT-7709677
IntAct P14780
DMDM 269849668
BREDNA 342435
Rectome R-HSA-1433557 R-HSA-3928665 R-HSA-1474228 R-HSA-1442490 R-HSA-1592389 R-HSA-2022090
SignaLink
BindingDB P14780

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.868 0.917 0.866 0.873 0.859 0.867 0.914 0.863 0.881 0.845 Download
MACCS fingerprints 0.792 0.887 0.798 0.766 0.831 0.800 0.904 0.803 0.764 0.845 Download
Daylight fingerprints 0.821 0.847 0.830 0.777 0.883 0.856 0.884 0.860 0.825 0.895 Download
ECFP2 fingerprints 0.900 0.950 0.897 0.923 0.871 0.917 0.961 0.912 0.960 0.861 Download
ECFP4 fingerprints 0.926 0.959 0.924 0.946 0.902 0.927 0.965 0.923 0.957 0.889 Download
ECFP6 fingerprints 0.919 0.958 0.918 0.920 0.916 0.927 0.965 0.925 0.937 0.912 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome,IE(Ver.>8).
 E-mail: biomed@csu.edu.cn