Details-Calcnet-AlzheimerNet

Target name

P16083: Ribosyldihydronicotinamide dehydrogenase [quinone]

Protein function

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Database links

Uniprot primary ID	P16083
PDB ID	3NHW 2QX6 2QX4 3O2N 2QX8 2QWX 2QX9 1SG0 2QR2 2BZS 3O73 3TEM 3TZB 3OWH 3UXE 3NHP 3UXH 4QOH 3OVM 3G5M 4U7F 4U7G 4U7H 1QR2 4GQI 1XI2 3OX2 3OWX 4FGK 4FGJ 2QMZ 3OX3 3GAM 3NHY 3NFR 3NHF 3NHK 3NHJ 3FW1 3NHL 3NHS 3NHR 4FGL 4GR9 4QOI 3NHU 4QOD 4QOE 4QOF 4QOG 2QMY
DrugBank ID	DB01065 DB03147 DB06695 DB00170 DB01087
BioGrid ID	110898
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA31745
KEGG ID	hsa:4835
BioCyc
Entrez Gene (Gene ID)	4835
DIP
STRING	9606ENSP00000337773
MINT	MINT-1133243
IntAct	P16083
DMDM	317373581
BREDNA	110992
Rectome
SignaLink
BindingDB	P16083

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.780	0.812	0.753	0.877	0.630	0.833	0.914	0.854	0.882	0.833	Download
MACCS fingerprints	0.759	0.842	0.764	0.750	0.778	0.698	0.848	0.683	0.833	0.565	Download
Daylight fingerprints	0.766	0.762	0.747	0.827	0.667	0.824	0.860	0.854	0.824	0.875	Download
ECFP2 fingerprints	0.686	0.774	0.667	0.728	0.605	0.789	0.939	0.805	0.882	0.750	Download
ECFP4 fingerprints	0.747	0.866	0.741	0.765	0.716	0.865	0.933	0.878	0.941	0.833	Download
ECFP6 fingerprints	0.778	0.867	0.778	0.778	0.778	0.833	0.924	0.854	0.882	0.833	Download

Download datasets

Positive dataset

Negative dataset