Details-Calcnet-AlzheimerNet

Target name

P17787: Neuronal acetylcholine receptor subunit beta-2

Protein function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.

Database links

Uniprot primary ID	P17787
PDB ID	2GVT 2K58 2K59 2KSR 2LM2
DrugBank ID	DB00184 DB00898 DB00674 DB00514
BioGrid ID
GuidetoPHARMACOLOGY ID	472
PharmGKB ID	PA115
KEGG ID	hsa:1141
BioCyc
Entrez Gene (Gene ID)	1141
DIP
STRING	9606ENSP00000357461
MINT	MINT-6629945
IntAct	P17787
DMDM	113105
BREDNA
Rectome	R-HSA-629587 R-HSA-629597 R-HSA-629594
SignaLink
BindingDB	P17787

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.805	0.863	0.803	0.814	0.791	0.806	0.869	0.798	0.844	0.751	Download
MACCS fingerprints	0.780	0.841	0.773	0.803	0.742	0.801	0.854	0.794	0.829	0.760	Download
Daylight fingerprints	0.709	0.716	0.713	0.698	0.727	0.714	0.705	0.708	0.734	0.682	Download
ECFP2 fingerprints	0.837	0.912	0.841	0.811	0.871	0.874	0.929	0.875	0.869	0.881	Download
ECFP4 fingerprints	0.861	0.922	0.867	0.820	0.915	0.891	0.937	0.893	0.879	0.905	Download
ECFP6 fingerprints	0.854	0.911	0.863	0.800	0.926	0.883	0.926	0.888	0.849	0.925	Download

Download datasets

Positive dataset

Negative dataset