Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
| Uniprot primary ID | P18054 |
| PDB ID | 2ABU 3D3L |
| DrugBank ID | |
| BioGrid ID | 106740 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA45 |
| KEGG ID | hsa:239 |
| BioCyc | MetaCyc:HS03167-MONOMER |
| Entrez Gene (Gene ID) | 239 |
| DIP | |
| STRING | 9606ENSP00000251535 |
| MINT | MINT-1206406 |
| IntAct | P18054 |
| DMDM | 125987838 |
| BREDNA | 1131131 |
| Rectome | R-HSA-2142712 R-HSA-2142696 R-HSA-2142700 |
| SignaLink | |
| BindingDB | P18054 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.545 | 0.590 | 0.545 | 0.600 | 0.500 | 0.444 | 0.669 | 0.590 | 0.476 | 0.650 | Download |
| MACCS fingerprints | 0.530 | 0.653 | 0.612 | 0.482 | 0.720 | 0.533 | 0.760 | 0.656 | 0.571 | 0.700 | Download |
| Daylight fingerprints | 0.563 | 0.599 | 0.595 | 0.573 | 0.614 | 0.500 | 0.607 | 0.607 | 0.571 | 0.625 | Download |
| ECFP2 fingerprints | 0.357 | 0.413 | 0.434 | 0.345 | 0.508 | 0.571 | 0.762 | 0.656 | 0.667 | 0.650 | Download |
| ECFP4 fingerprints | 0.482 | 0.585 | 0.529 | 0.482 | 0.568 | 0.553 | 0.781 | 0.656 | 0.619 | 0.675 | Download |
| ECFP6 fingerprints | 0.550 | 0.611 | 0.587 | 0.555 | 0.614 | 0.511 | 0.785 | 0.623 | 0.571 | 0.650 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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