Details-Calcnet-AlzheimerNet

Target name

P19438: Tumor necrosis factor receptor superfamily member 1A

Protein function

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

Database links

Uniprot primary ID	P19438
PDB ID	1FT4 1ICH 1EXT 1NCF 1TNR
DrugBank ID
BioGrid ID	112986
GuidetoPHARMACOLOGY ID	1870
PharmGKB ID	PA36609
KEGG ID	hsa:7132
BioCyc
Entrez Gene (Gene ID)	7132
DIP	DIP-407N
STRING	9606ENSP00000162749
MINT	MINT-135026
IntAct	P19438
DMDM	135959
BREDNA
Rectome	R-HSA-75893 R-HSA-5357786 R-HSA-5669034
SignaLink
BindingDB	P19438

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.778	0.804	0.789	0.747	0.830	0.833	0.832	0.818	0.833	0.800	Download
MACCS fingerprints	0.807	0.872	0.806	0.816	0.795	0.844	0.895	0.841	0.792	0.900	Download
Daylight fingerprints	0.747	0.791	0.783	0.644	0.920	0.844	0.846	0.841	0.792	0.900	Download
ECFP2 fingerprints	0.839	0.858	0.829	0.897	0.761	0.902	0.948	0.886	0.958	0.800	Download
ECFP4 fingerprints	0.849	0.887	0.840	0.908	0.773	0.902	0.914	0.886	0.958	0.800	Download
ECFP6 fingerprints	0.822	0.884	0.817	0.851	0.784	0.880	0.910	0.864	0.917	0.800	Download

Download datasets

Positive dataset

Negative dataset