Details-Calcnet-AlzheimerNet

Target name

P21397: Amine oxidase [flavin-containing] A

Protein function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Database links

Uniprot primary ID	P21397
PDB ID	2BXR 2BXS 1H8Q 2Z5Y 2Z5X
DrugBank ID	DB00953 DB00952 DB00752 DB01626 DB08804 DB00614 DB01104 DB00388 DB00918 DB00624 DB00780 DB00852 DB00140 DB01037 DB00184 DB03147 DB00669 DB00721 DB00601 DB00315 DB01171 DB00805 DB00909 DB00397 DB01363 DB00988 DB01247 DB01577 DB00191
BioGrid ID	110301
GuidetoPHARMACOLOGY ID	2489
PharmGKB ID	PA236
KEGG ID	hsa:4128
BioCyc	MetaCyc:HS01798-MONOMER
Entrez Gene (Gene ID)	4128
DIP
STRING	9606ENSP00000340684
MINT	MINT-4054607
IntAct	P21397
DMDM	113978
BREDNA	1434
Rectome	R-HSA-181430 R-HSA-380612 R-HSA-379397 R-HSA-379398 R-HSA-5579012 R-HSA-141333
SignaLink
BindingDB	P21397

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.642	0.715	0.652	0.628	0.675	0.694	0.761	0.701	0.713	0.690	Download
MACCS fingerprints	0.697	0.724	0.668	0.768	0.570	0.693	0.758	0.664	0.797	0.544	Download
Daylight fingerprints	0.609	0.658	0.615	0.603	0.627	0.722	0.743	0.711	0.790	0.639	Download
ECFP2 fingerprints	0.674	0.720	0.662	0.701	0.623	0.721	0.795	0.718	0.769	0.671	Download
ECFP4 fingerprints	0.711	0.773	0.710	0.716	0.704	0.752	0.814	0.754	0.783	0.728	Download
ECFP6 fingerprints	0.693	0.769	0.692	0.699	0.684	0.747	0.823	0.748	0.783	0.715	Download

Download datasets

Positive dataset

Negative dataset