Target name

P21728: D(1A) dopamine receptor


  Protein function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

  Database links

Uniprot primary ID P21728
PDB ID 1OZ5
DrugBank ID DB00777 DB06148 DB01063 DB01624 DB01608 DB01623 DB01621 DB00850 DB06216 DB00875 DB00502 DB01239 DB01238 DB01235 DB01049 DB00568 DB00408 DB00370 DB01403 DB00623 DB00679 DB00353 DB00420 DB00589 DB01614 DB01622 DB00334 DB05271 DB04946 DB00726 DB00246 DB00543
BioGrid ID 108146
GuidetoPHARMACOLOGY ID 214
PharmGKB ID PA147
KEGG ID hsa:1812
BioCyc
Entrez Gene (Gene ID) 1812
DIP
STRING 9606ENSP00000327652
MINT MINT-123019
IntAct
DMDM 118228
BREDNA
Rectome R-HSA-418555 R-HSA-390651
SignaLink
BindingDB P21728

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.671 0.776 0.731 0.547 0.916 0.702 0.803 0.755 0.585 0.921 Download
MACCS fingerprints 0.698 0.773 0.692 0.710 0.674 0.728 0.806 0.731 0.743 0.720 Download
Daylight fingerprints 0.649 0.709 0.695 0.564 0.825 0.673 0.755 0.707 0.610 0.802 Download
ECFP2 fingerprints 0.745 0.852 0.753 0.723 0.783 0.791 0.883 0.793 0.792 0.793 Download
ECFP4 fingerprints 0.784 0.880 0.803 0.716 0.890 0.799 0.899 0.812 0.758 0.864 Download
ECFP6 fingerprints 0.777 0.863 0.805 0.682 0.928 0.799 0.891 0.820 0.725 0.913 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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