Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
| Uniprot primary ID | P21917 |
| PDB ID | |
| DrugBank ID | DB00777 DB00734 DB04946 DB01238 DB01235 DB00268 DB00409 DB00408 DB01403 DB00543 DB00589 DB05271 DB00334 DB06216 DB00413 DB01200 DB01267 DB00248 DB01186 DB00477 DB00988 DB01224 DB00714 DB00363 DB00246 DB00420 |
| BioGrid ID | 108149 |
| GuidetoPHARMACOLOGY ID | 217 |
| PharmGKB ID | PA27480 |
| KEGG ID | hsa:1815 |
| BioCyc | |
| Entrez Gene (Gene ID) | 1815 |
| DIP | DIP-59865N |
| STRING | |
| MINT | MINT-8090293 |
| IntAct | |
| DMDM | 1345939 |
| BREDNA | |
| Rectome | R-HSA-418594 R-HSA-390651 |
| SignaLink | |
| BindingDB | P21917 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.814 | 0.872 | 0.808 | 0.841 | 0.775 | 0.839 | 0.896 | 0.826 | 0.887 | 0.763 | Download |
| MACCS fingerprints | 0.832 | 0.893 | 0.818 | 0.898 | 0.738 | 0.826 | 0.887 | 0.812 | 0.886 | 0.736 | Download |
| Daylight fingerprints | 0.741 | 0.748 | 0.737 | 0.748 | 0.726 | 0.744 | 0.741 | 0.734 | 0.759 | 0.708 | Download |
| ECFP2 fingerprints | 0.873 | 0.945 | 0.871 | 0.891 | 0.851 | 0.903 | 0.965 | 0.900 | 0.908 | 0.892 | Download |
| ECFP4 fingerprints | 0.888 | 0.955 | 0.889 | 0.877 | 0.901 | 0.921 | 0.967 | 0.920 | 0.917 | 0.923 | Download |
| ECFP6 fingerprints | 0.870 | 0.948 | 0.875 | 0.834 | 0.916 | 0.901 | 0.963 | 0.902 | 0.876 | 0.928 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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