Target name

P21917: D(4) dopamine receptor


  Protein function

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

  Database links

Uniprot primary ID P21917
PDB ID
DrugBank ID DB00777 DB00734 DB04946 DB01238 DB01235 DB00268 DB00409 DB00408 DB01403 DB00543 DB00589 DB05271 DB00334 DB06216 DB00413 DB01200 DB01267 DB00248 DB01186 DB00477 DB00988 DB01224 DB00714 DB00363 DB00246 DB00420
BioGrid ID 108149
GuidetoPHARMACOLOGY ID 217
PharmGKB ID PA27480
KEGG ID hsa:1815
BioCyc
Entrez Gene (Gene ID) 1815
DIP DIP-59865N
STRING
MINT MINT-8090293
IntAct
DMDM 1345939
BREDNA
Rectome R-HSA-418594 R-HSA-390651
SignaLink
BindingDB P21917

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.814 0.872 0.808 0.841 0.775 0.839 0.896 0.826 0.887 0.763 Download
MACCS fingerprints 0.832 0.893 0.818 0.898 0.738 0.826 0.887 0.812 0.886 0.736 Download
Daylight fingerprints 0.741 0.748 0.737 0.748 0.726 0.744 0.741 0.734 0.759 0.708 Download
ECFP2 fingerprints 0.873 0.945 0.871 0.891 0.851 0.903 0.965 0.900 0.908 0.892 Download
ECFP4 fingerprints 0.888 0.955 0.889 0.877 0.901 0.921 0.967 0.920 0.917 0.923 Download
ECFP6 fingerprints 0.870 0.948 0.875 0.834 0.916 0.901 0.963 0.902 0.876 0.928 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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