Target name

P22102: Trifunctional purine biosynthetic protein adenosine-3


  Protein function

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.

  Database links

Uniprot primary ID P22102
PDB ID 1NJS 4EW1 4EW2 4EW3 1RBQ 1RBM 1RBZ 1MEJ 1RC0 1RC1 1MEO 1MEN 1ZLY 1ZLX 2V9Y 2QK4 1RBY
DrugBank ID DB00642
BioGrid ID 108888
GuidetoPHARMACOLOGY ID
PharmGKB ID PA28576
KEGG ID hsa:2618
BioCyc MetaCyc:HS08358-MONOMER
Entrez Gene (Gene ID) 2618
DIP
STRING 9606ENSP00000371236
MINT MINT-1143007
IntAct P22102
DMDM 131616
BREDNA 2122
Rectome R-HSA-73817
SignaLink
BindingDB P22102

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.867 0.854 0.849 0.984 0.714 0.857 0.847 0.813 1.000 0.571 Download
MACCS fingerprints 0.849 0.897 0.825 0.984 0.667 0.857 0.927 0.813 1.000 0.571 Download
Daylight fingerprints 0.831 0.839 0.810 0.937 0.683 0.857 0.786 0.813 1.000 0.571 Download
ECFP2 fingerprints 0.832 0.812 0.802 0.984 0.619 0.857 0.954 0.813 1.000 0.571 Download
ECFP4 fingerprints 0.838 0.848 0.810 0.984 0.635 0.857 0.893 0.813 1.000 0.571 Download
ECFP6 fingerprints 0.836 0.850 0.810 0.968 0.651 0.857 0.821 0.813 1.000 0.571 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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