Target name

P23219: Prostaglandin G/H synthase 1


  Protein function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

  Database links

Uniprot primary ID P23219
PDB ID
DrugBank ID DB01419 DB00619 DB00159 DB00773 DB01029 DB01435 DB00327 DB00672 DB00154 DB00939 DB00784 DB00814 DB04552 DB00328 DB00936 DB00500 DB00250 DB00461 DB00870 DB00465 DB01198 DB00857 DB00469 DB05109 DB01355 DB01132 DB00549 DB01401 DB01399 DB00313 DB08814 DB01221
BioGrid ID 111714
GuidetoPHARMACOLOGY ID 1375
PharmGKB ID PA24346
KEGG ID hsa:5742
BioCyc MetaCyc:HS01815-MONOMER
Entrez Gene (Gene ID) 5742
DIP
STRING 9606ENSP00000354612
MINT MINT-4530066
IntAct P23219
DMDM 317373262
BREDNA 114991
Rectome R-HSA-140180 R-HSA-2162123
SignaLink
BindingDB P23219

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.546 0.679 0.647 0.615 0.664 0.523 0.695 0.628 0.612 0.636 Download
MACCS fingerprints 0.429 0.601 0.599 0.437 0.684 0.505 0.651 0.644 0.544 0.694 Download
Daylight fingerprints 0.505 0.614 0.598 0.596 0.599 0.526 0.632 0.615 0.641 0.602 Download
ECFP2 fingerprints 0.383 0.650 0.651 0.315 0.828 0.461 0.778 0.712 0.369 0.883 Download
ECFP4 fingerprints 0.552 0.735 0.699 0.538 0.784 0.606 0.811 0.748 0.583 0.830 Download
ECFP6 fingerprints 0.564 0.745 0.691 0.580 0.749 0.648 0.814 0.761 0.660 0.811 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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