Details-Calcnet-AlzheimerNet

Target name

P24385: G1/S-specific cyclin-D1

Protein function

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G

Database links

Uniprot primary ID	P24385
PDB ID	2W9Z 2W96 2W99 2W9F
DrugBank ID	DB01169
BioGrid ID	107067
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA75
KEGG ID	hsa:595
BioCyc
Entrez Gene (Gene ID)	595
DIP	DIP-123N
STRING	9606ENSP00000227507
MINT	MINT-135422
IntAct	P24385
DMDM	116152
BREDNA
Rectome	R-HSA-3214858 R-HSA-1912408 R-HSA-69229 R-HSA-69231
SignaLink	P24385
BindingDB	P24385

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.837	0.886	0.834	0.843	0.825	0.875	0.907	0.876	0.872	0.879	Download
MACCS fingerprints	0.774	0.828	0.750	0.844	0.654	0.795	0.868	0.782	0.852	0.714	Download
Daylight fingerprints	0.764	0.766	0.751	0.794	0.707	0.757	0.783	0.765	0.740	0.789	Download
ECFP2 fingerprints	0.862	0.929	0.855	0.893	0.816	0.902	0.964	0.896	0.959	0.834	Download
ECFP4 fingerprints	0.878	0.947	0.880	0.855	0.905	0.917	0.972	0.919	0.903	0.935	Download
ECFP6 fingerprints	0.866	0.940	0.871	0.818	0.927	0.918	0.964	0.922	0.888	0.955	Download

Download datasets

Positive dataset

Negative dataset