Target name

P24385: G1/S-specific cyclin-D1


  Protein function

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G

  Database links

Uniprot primary ID P24385
PDB ID 2W9Z 2W96 2W99 2W9F
DrugBank ID DB01169
BioGrid ID 107067
GuidetoPHARMACOLOGY ID
PharmGKB ID PA75
KEGG ID hsa:595
BioCyc
Entrez Gene (Gene ID) 595
DIP DIP-123N
STRING 9606ENSP00000227507
MINT MINT-135422
IntAct P24385
DMDM 116152
BREDNA
Rectome R-HSA-3214858 R-HSA-1912408 R-HSA-69229 R-HSA-69231
SignaLink P24385
BindingDB P24385

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.837 0.886 0.834 0.843 0.825 0.875 0.907 0.876 0.872 0.879 Download
MACCS fingerprints 0.774 0.828 0.750 0.844 0.654 0.795 0.868 0.782 0.852 0.714 Download
Daylight fingerprints 0.764 0.766 0.751 0.794 0.707 0.757 0.783 0.765 0.740 0.789 Download
ECFP2 fingerprints 0.862 0.929 0.855 0.893 0.816 0.902 0.964 0.896 0.959 0.834 Download
ECFP4 fingerprints 0.878 0.947 0.880 0.855 0.905 0.917 0.972 0.919 0.903 0.935 Download
ECFP6 fingerprints 0.866 0.940 0.871 0.818 0.927 0.918 0.964 0.922 0.888 0.955 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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