Target name

P25025: C-X-C chemokine receptor type 2


  Protein function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

  Database links

Uniprot primary ID P25025
PDB ID 4Q3H
DrugBank ID
BioGrid ID 109793
GuidetoPHARMACOLOGY ID 69
PharmGKB ID PA29843
KEGG ID hsa:3579
BioCyc
Entrez Gene (Gene ID) 3579
DIP DIP-3782N
STRING 9606ENSP00000319635
MINT MINT-271138
IntAct P25025
DMDM 1352454
BREDNA
Rectome R-HSA-418594 R-HSA-380108
SignaLink P25025
BindingDB P25025

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.871 0.926 0.883 0.787 0.981 0.877 0.924 0.889 0.802 0.975 Download
MACCS fingerprints 0.824 0.909 0.831 0.785 0.877 0.833 0.921 0.838 0.819 0.857 Download
Daylight fingerprints 0.800 0.838 0.826 0.692 0.961 0.789 0.814 0.800 0.759 0.840 Download
ECFP2 fingerprints 0.928 0.975 0.929 0.909 0.948 0.940 0.985 0.940 0.940 0.941 Download
ECFP4 fingerprints 0.951 0.974 0.951 0.932 0.970 0.957 0.982 0.957 0.957 0.958 Download
ECFP6 fingerprints 0.937 0.977 0.938 0.905 0.972 0.952 0.983 0.953 0.940 0.966 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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