Details-Calcnet-AlzheimerNet

Target name

P25098: Beta-adrenergic receptor kinase 1

Protein function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Database links

Uniprot primary ID	P25098
PDB ID	3KRX 4PNK 1BAK 3CIK 3V5W 4MK0 3KRW
DrugBank ID	DB00171
BioGrid ID	106665
GuidetoPHARMACOLOGY ID	1466
PharmGKB ID	PA40
KEGG ID	hsa:156
BioCyc
Entrez Gene (Gene ID)	156
DIP	DIP-42429N
STRING	9606ENSP00000312262
MINT	MINT-1214643
IntAct	P25098
DMDM	126302521
BREDNA	271115
Rectome	R-HSA-111933 R-HSA-5635838 R-HSA-416476
SignaLink	P25098
BindingDB	P25098

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.653	0.720	0.715	0.532	0.902	0.733	0.777	0.742	0.647	0.857	Download
MACCS fingerprints	0.614	0.631	0.639	0.574	0.705	0.621	0.650	0.645	0.563	0.733	Download
Daylight fingerprints	0.653	0.717	0.715	0.532	0.902	0.733	0.752	0.742	0.647	0.857	Download
ECFP2 fingerprints	0.555	0.506	0.569	0.532	0.607	0.733	0.676	0.742	0.647	0.857	Download
ECFP4 fingerprints	0.641	0.590	0.699	0.532	0.869	0.733	0.727	0.742	0.647	0.857	Download
ECFP6 fingerprints	0.653	0.679	0.715	0.532	0.902	0.733	0.742	0.742	0.647	0.857	Download

Download datasets

Positive dataset

Negative dataset