Target name

P25098: Beta-adrenergic receptor kinase 1


  Protein function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

  Database links

Uniprot primary ID P25098
PDB ID 3KRX 4PNK 1BAK 3CIK 3V5W 4MK0 3KRW
DrugBank ID DB00171
BioGrid ID 106665
GuidetoPHARMACOLOGY ID 1466
PharmGKB ID PA40
KEGG ID hsa:156
BioCyc
Entrez Gene (Gene ID) 156
DIP DIP-42429N
STRING 9606ENSP00000312262
MINT MINT-1214643
IntAct P25098
DMDM 126302521
BREDNA 271115
Rectome R-HSA-111933 R-HSA-5635838 R-HSA-416476
SignaLink P25098
BindingDB P25098

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.653 0.720 0.715 0.532 0.902 0.733 0.777 0.742 0.647 0.857 Download
MACCS fingerprints 0.614 0.631 0.639 0.574 0.705 0.621 0.650 0.645 0.563 0.733 Download
Daylight fingerprints 0.653 0.717 0.715 0.532 0.902 0.733 0.752 0.742 0.647 0.857 Download
ECFP2 fingerprints 0.555 0.506 0.569 0.532 0.607 0.733 0.676 0.742 0.647 0.857 Download
ECFP4 fingerprints 0.641 0.590 0.699 0.532 0.869 0.733 0.727 0.742 0.647 0.857 Download
ECFP6 fingerprints 0.653 0.679 0.715 0.532 0.902 0.733 0.742 0.742 0.647 0.857 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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