Details-Calcnet-AlzheimerNet

Target name

P27338: Amine oxidase [flavin-containing] B

Protein function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Database links

Uniprot primary ID	P27338
PDB ID	1OJC 2VZ2 3PO7 1S3E 1OJD 4A79 1OJA 2C75 2C76 2C70 2C72 2C73 1S3B 4CRT 2V5Z 1S2Q 1S2Y 1GOS 2XFO 2XFP 2XFQ 2BK3 2BK5 2XFU 2V60 2V61 2XFN 4A7A 1OJ9 2C67 2BYB 2C65 2C64 3ZYX 1H8R 2C66 2XCG 2VRM 2VRL 2BK4
DrugBank ID	DB01363 DB03147 DB00752 DB01367 DB08804 DB01626 DB00614 DB00780 DB01247 DB00988 DB01104 DB01577 DB00182 DB00721 DB00184 DB00915 DB01171 DB01037 DB00601 DB00191 DB00909
BioGrid ID	110302
GuidetoPHARMACOLOGY ID	2490
PharmGKB ID	PA237
KEGG ID	hsa:4129
BioCyc	MetaCyc:HS00966-MONOMER
Entrez Gene (Gene ID)	4129
DIP
STRING	9606ENSP00000367309
MINT	MINT-3010688
IntAct	P27338
DMDM	113980
BREDNA	1434
Rectome	R-HSA-141333
SignaLink
BindingDB	P27338

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.749	0.808	0.756	0.740	0.772	0.793	0.867	0.799	0.811	0.787	Download
MACCS fingerprints	0.689	0.774	0.691	0.697	0.686	0.729	0.802	0.727	0.771	0.688	Download
Daylight fingerprints	0.629	0.662	0.648	0.606	0.689	0.637	0.684	0.668	0.612	0.719	Download
ECFP2 fingerprints	0.763	0.849	0.757	0.797	0.718	0.789	0.883	0.780	0.866	0.701	Download
ECFP4 fingerprints	0.784	0.868	0.788	0.783	0.793	0.809	0.896	0.806	0.866	0.751	Download
ECFP6 fingerprints	0.760	0.863	0.775	0.723	0.825	0.793	0.888	0.796	0.821	0.774	Download

Download datasets

Positive dataset

Negative dataset