Target name

P27338: Amine oxidase [flavin-containing] B


  Protein function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

  Database links

Uniprot primary ID P27338
PDB ID 1OJC 2VZ2 3PO7 1S3E 1OJD 4A79 1OJA 2C75 2C76 2C70 2C72 2C73 1S3B 4CRT 2V5Z 1S2Q 1S2Y 1GOS 2XFO 2XFP 2XFQ 2BK3 2BK5 2XFU 2V60 2V61 2XFN 4A7A 1OJ9 2C67 2BYB 2C65 2C64 3ZYX 1H8R 2C66 2XCG 2VRM 2VRL 2BK4
DrugBank ID DB01363 DB03147 DB00752 DB01367 DB08804 DB01626 DB00614 DB00780 DB01247 DB00988 DB01104 DB01577 DB00182 DB00721 DB00184 DB00915 DB01171 DB01037 DB00601 DB00191 DB00909
BioGrid ID 110302
GuidetoPHARMACOLOGY ID 2490
PharmGKB ID PA237
KEGG ID hsa:4129
BioCyc MetaCyc:HS00966-MONOMER
Entrez Gene (Gene ID) 4129
DIP
STRING 9606ENSP00000367309
MINT MINT-3010688
IntAct P27338
DMDM 113980
BREDNA 1434
Rectome R-HSA-141333
SignaLink
BindingDB P27338

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.749 0.808 0.756 0.740 0.772 0.793 0.867 0.799 0.811 0.787 Download
MACCS fingerprints 0.689 0.774 0.691 0.697 0.686 0.729 0.802 0.727 0.771 0.688 Download
Daylight fingerprints 0.629 0.662 0.648 0.606 0.689 0.637 0.684 0.668 0.612 0.719 Download
ECFP2 fingerprints 0.763 0.849 0.757 0.797 0.718 0.789 0.883 0.780 0.866 0.701 Download
ECFP4 fingerprints 0.784 0.868 0.788 0.783 0.793 0.809 0.896 0.806 0.866 0.751 Download
ECFP6 fingerprints 0.760 0.863 0.775 0.723 0.825 0.793 0.888 0.796 0.821 0.774 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome,IE(Ver.>8).
 E-mail: biomed@csu.edu.cn