Target name

P27986: Phosphatidylinositol 3-kinase regulatory subunit alpha


  Protein function

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:

  Database links

Uniprot primary ID P27986
PDB ID 4YKN 1AZG 1PHT 4A55 3I5S 3I5R 4L2Y 4JPS 2RD0 1PBW 1H9O 3HHM 4L1B 1PIC 2V1Y 1PKS 2IUH 2IUI 1PKT 1A0N 2IUG 4OVU 4OVV 4WAF 3HIZ 4L23
DrugBank ID DB01064
BioGrid ID 111313
GuidetoPHARMACOLOGY ID
PharmGKB ID PA33312
KEGG ID hsa:5295
BioCyc MetaCyc:ENSG00000145675-MONOMER
Entrez Gene (Gene ID) 5295
DIP DIP-119N
STRING 9606ENSP00000274335
MINT MINT-93751
IntAct P27986
DMDM 118572681
BREDNA 271153
Rectome R-HSA-1660499 R-HSA-4420097 R-HSA-1266695 R-HSA-198203 R-HSA-5655332 R-HSA-5654710 R-HSA-5654720 R-HSA-114604 R-HSA-2219530 R-HSA-1963642 R-HSA-430116 R-HSA-5637810 R-HSA-186763 R-HSA-180292 R-HSA-1257604 R-HSA-912631 R-HSA-389 R-HSA-5654689 R-HSA-2730905
SignaLink P27986
BindingDB P27986

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.924 0.937 0.928 0.878 0.978 0.941 0.950 0.939 0.903 0.981 Download
MACCS fingerprints 0.862 0.915 0.860 0.870 0.851 0.887 0.940 0.878 0.887 0.868 Download
Daylight fingerprints 0.879 0.889 0.878 0.887 0.868 0.906 0.906 0.896 0.935 0.849 Download
ECFP2 fingerprints 0.926 0.977 0.928 0.891 0.965 0.943 0.990 0.939 0.935 0.943 Download
ECFP4 fingerprints 0.926 0.965 0.930 0.874 0.987 0.959 0.986 0.957 0.935 0.981 Download
ECFP6 fingerprints 0.928 0.955 0.932 0.870 0.996 0.959 0.981 0.957 0.935 0.981 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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